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A slice of creamy chicken Alfredo lasagna is being lifted from a speckled baking dish, revealing layers of cheese and sauce. A bowl of fresh greens is in the background.

Easy Chicken Alfredo Lasagna Recipe

Chicken Alfredo Lasagna layers tender chicken, spinach, and creamy Parmesan Alfredo sauce between pasta layers. This make-ahead dinner feeds a crowd from one dish, and the leftovers freeze well for later.
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Prep Time: 25 minutes
Cook Time: 40 minutes
Total Time: 1 hour 5 minutes
Course: Main Course
Cuisine: Italian
Keyword: Chicken Alfredo Lasagna
Servings: 8
Calories: 694kcal

Ingredients

For the chicken:

  • 4 cups cooked shredded chicken
  • 1 teaspoon garlic powder
  • 1 teaspoon paprika powder
  • Salt and pepper

Spinach Alfredo sauce:

  • ¼ cup unsalted butter
  • 4 tablespoons all-purpose flour
  • 2 cups whole milk
  • 1 tablespoon minced garlic
  • 2 teaspoons Italian seasoning
  • 1 cup heavy cream
  • 2 cups shredded mozzarella cheese
  • 2 cups chopped spinach
  • Salt and pepper

Assembly:

  • 14-15 lasagna sheets almost 1 pack
  • 1 cup ricotta cheese optional
  • 1 cup Parmesan cheese

Instructions

  • If you need to precook your sheets, then boil the lasagna sheets in a pot of water just until they’re soft enough to bend, or follow the package instructions if using oven-ready sheets. Lay them flat on a tray to prevent sticking.
    14-15 lasagna sheets
  • Preheat your oven to 350°F (180°C) and grease a 9x13-inch baking dish.
  • In a bowl, season the cooked shredded chicken with garlic powder, paprika, salt, and pepper, mixing well to coat evenly.
    4 cups cooked shredded chicken, 1 teaspoon garlic powder, 1 teaspoon paprika powder, Salt and pepper
  • Melt butter in a large skillet over medium heat, whisking in the flour to create a thick paste. Add the minced garlic and gradually whisk in the milk. Stir continuously until the mixture begins to thicken.
    ¼ cup unsalted butter, 4 tablespoons all-purpose flour, 2 cups whole milk, 1 tablespoon minced garlic
  • Reduce heat and mix in the mozzarella cheese, heavy cream, Italian seasoning, spinach, salt, and pepper. Stir until the cheese has melted and the sauce is smooth. Adjust with more milk if needed for a thinner consistency.
    2 teaspoons Italian seasoning, 1 cup heavy cream, 2 cups shredded mozzarella cheese, 2 cups chopped spinach, Salt and pepper
  • In the prepared baking dish, layer a bit of the spinach Alfredo sauce on the bottom. Add a layer of lasagna sheets, spread ricotta cheese (if using), top with seasoned chicken, and then more sauce. Repeat the layers, finishing with a generous layer of spinach Alfredo sauce on top. Sprinkle Parmesan cheese evenly across the top.
    1 cup ricotta cheese, 1 cup Parmesan cheese
  • Bake for 35-40 minutes, or until the top is golden brown and the sauce is bubbling.

Notes

  • Boil the lasagna sheets only until pliable; they finish cooking in the oven. Skip this step with oven-ready sheets.
  • Thaw and squeeze frozen spinach very dry so the sauce does not turn watery.
  • Keep the alfredo sauce loose before layering; the sheets absorb liquid as it bakes.
  • Spread each layer evenly so every slice gets sauce, chicken, and cheese.
  • Season the chicken and sauce well; it ties the dish together.
  • If the sauce feels too thick, add milk a little at a time until it loosens.
  • For a browned top, broil the last 2 to 3 minutes and watch closely.
  • Reheat leftovers in a 350°F (177°C) oven until the center reaches 165°F (74°C).

Nutrition

Calories: 694kcal | Carbohydrates: 46g | Protein: 42g | Fat: 37g | Saturated Fat: 21g | Polyunsaturated Fat: 3g | Monounsaturated Fat: 10g | Trans Fat: 0.2g | Cholesterol: 155mg | Sodium: 496mg | Potassium: 523mg | Fiber: 2g | Sugar: 6g | Vitamin A: 2002IU | Vitamin C: 3mg | Calcium: 487mg | Iron: 3mg
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